𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Biochemistry and molecular biology of chronic granulomatous disease

✍ Scribed by A. W. Segal


Publisher
Springer
Year
1992
Tongue
English
Weight
279 KB
Volume
15
Category
Article
ISSN
0141-8955

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## To the Editor: Chronic granulomatous disease (CGD) is a rare genetic disorder of phagocyte oxidative metabolism. In addition to infectious complications, granulomatous lesions can involve the gastrointestinal (GI) tract and can mimic ulcerative colitis or Crohn's disease. 1,2 Crohn's-like manife

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The molecular and biochemical characterization of many components of the phagocyte oxidase complex that generates superoxide have greatly advanced our understanding of this important pathway. Genetic defects in one or more of the components of this host defense system result in the chronic granuloma