Chronic granulomatous disease—Pieces of a cellular and molecular puzzle
✍ Scribed by B.M. Babior; J.T. Curnutte
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 594 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0268-960X
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📜 SIMILAR VOLUMES
## Chronic granulomatous disease (CGD) is an uncommon inherited disorder of phagocytic cells in which a defective respiratory burst leads to severe recurrent bacterial and fungal infections. The disease is a consequence of mutations in one of the four molecules that constitute the NADPH oxidase sys
Chronic granulomatous disease (CGD) results from constitutional inactivating mutations in the CYBB, NCF1, CYBA or NCF2 genes that encode subunits of phagocyte NADPH oxidase. We report the findings of molecular analysis of 80 kindred. In 75 unrelated male and 5 female probands, CGD was suspected on t