๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Prenatal diagnosis of chronic granulomatous disease

โœ Scribed by Matthay, Katherine K. ;Golbus, Mitchell S. ;Wara, Diane W. ;Mentzer, William C. ;Karp, Laurence E.

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
515 KB
Volume
17
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

โœฆ Synopsis

A luminol enhanced chemiluminescence micromethod has been adapted for use in prenatal diagnosis of chronic granulomatous disease (CGD). After validation of the assay in normal adults, newborns, fetuses, CGD carriers, and CGD patients, the fetuses of two pregnant CGD carriers were tested after fetoscopic aspiration of fetal blood. Normal neutrophil chemiluminescence and nitroblue tetrazolium slide tests were followed by delivery of two healthy infants whose normality was confirmed. Amniocytes proved useless for the prenatal diagnosis of CGD. They were found to have negligible nitroblue tetrazolium reduction, oxygen metabolism, and oxygen dependence.

๐Ÿ“œ SIMILAR VOLUMES

Chronic granulomatous disease
Chronic granulomatous disease
โœ Erik C. von Rosenvinge; Thomas G. O'Donnell; Steven M. Holland; Theo Heller ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 66 KB

## To the Editor: Chronic granulomatous disease (CGD) is a rare genetic disorder of phagocyte oxidative metabolism. In addition to infectious complications, granulomatous lesions can involve the gastrointestinal (GI) tract and can mimic ulcerative colitis or Crohn's disease. 1,2 Crohn's-like manife

Chronic granulomatous disease
Chronic granulomatous disease
โœ F. Bassani; F. Capsoni; A. Lazzarin; A. Rossi ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 860 KB
Interferon-ฮณ and chronic granulomatous d
Interferon-ฮณ and chronic granulomatous disease
โœ Mary C. Dinauer; R.Alan B. Ezekowitz ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 505 KB

The molecular and biochemical characterization of many components of the phagocyte oxidase complex that generates superoxide have greatly advanced our understanding of this important pathway. Genetic defects in one or more of the components of this host defense system result in the chronic granuloma

Chronic granulomatous disease, a heterog
Chronic granulomatous disease, a heterogeneous syndrome
โœ W. H. Hitzig; R. A. Seger ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 965 KB

Chronic granulomatous disease (CGD) is a clinical syndrome, the unifying characteristics of which are a severe predisposition to bacterial and fungal infections, an impaired ability of phagocytic leukocytes to kill certain microorganisms and the failure of these cells to produce microbicidal oxygen