## To the Editor: Chronic granulomatous disease (CGD) is a rare genetic disorder of phagocyte oxidative metabolism. In addition to infectious complications, granulomatous lesions can involve the gastrointestinal (GI) tract and can mimic ulcerative colitis or Crohn's disease. 1,2 Crohn's-like manife
Chronic granulomatous disease
โ Scribed by F. Bassani; F. Capsoni; A. Lazzarin; A. Rossi
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 860 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0301-0449
No coin nor oath required. For personal study only.
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The molecular and biochemical characterization of many components of the phagocyte oxidase complex that generates superoxide have greatly advanced our understanding of this important pathway. Genetic defects in one or more of the components of this host defense system result in the chronic granuloma
Chronic granulomatous disease (CGD) is a clinical syndrome, the unifying characteristics of which are a severe predisposition to bacterial and fungal infections, an impaired ability of phagocytic leukocytes to kill certain microorganisms and the failure of these cells to produce microbicidal oxygen