A two-parameter (admixture) test (Lod,) for the detection of linkage which allows for heterogeneity is described. Lod score values for this test which lead to comparable type 1 error probabilities as the conventional (homogeneous) single-parameter lod score test (Lod,) are derived. For example, a Lo
Linkage detection under heterogeneity and the mixture problem
β Scribed by M. N. CHIANO; J. R. W. YATES
- Book ID
- 115249688
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 771 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0003-4800
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## Abstract The admixture test for the detection of linkage under heterogeneity is considered. We show that the null distribution of this test statistic has half its weight concentrated on zero and the other half on a complicated distribution that can be approximated by max (__X__~1~, __X__ ~2~ ) w
## Abstract A major reason for the slow progress in identifying susceptibility genes for complex diseases may be that the clinical diagnoses used as phenotypes are genetically heterogeneous. This has led researchers to collect various phenotypes related to the diagnosis, such as detailed symptoms,
Linkage analysis under the two-locus model and the admixture model was compared on pedigree data for a common disease simulated under a model of genetic heterogeneity. The ascertainment of families was designed so that the samples had a large proportion of families segregating for both disease loci.