𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Detection of linkage under heterogeneity: Comparison of the two-locus vs. admixture models

✍ Scribed by Lynn R. Goldin; G. P. Vogler

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
343 KB
Volume
9
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

Linkage analysis under the two-locus model and the admixture model was compared on pedigree data for a common disease simulated under a model of genetic heterogeneity. The ascertainment of families was designed so that the samples had a large proportion of families segregating for both disease loci. The two-locus linkage analysis model did not demonstrate increased power of detecting linkage or more accurate estimates of the recombination fraction, 8 than did the admixture model linkage analysis. When a sample was purposely chosen so that all of the families were segregating for both loci, then the two-locus lod score analysis was better. However, the increased power depended on assuming the correct gene frequency for the linked locus. It can be concluded that under the conditions of genetic heterogeneity examined here, testing for linkage under the admixture model is the preferred method of analysis. However, this is not a general conclusion that can apply to all two-locus disease models. Published 1992 by Wiley-Liss, Inc.

📜 SIMILAR VOLUMES

Distribution of the admixture test for t
Distribution of the admixture test for the detection of linkage under heterogeneity
✍ Julian J. Faraway 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 377 KB 👁 1 views

## Abstract The admixture test for the detection of linkage under heterogeneity is considered. We show that the null distribution of this test statistic has half its weight concentrated on zero and the other half on a complicated distribution that can be approximated by max (__X__~1~, __X__ ~2~ ) w

Two new approaches toward linkage hetero
Two new approaches toward linkage heterogeneity of FAD: Two-locus models and age of onset as a discriminator
✍ Dr. Chantal Mérette; Thomas Lehner; Jurg Ott 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 272 KB

We present two new approaches to the problem of genetic heterogeneity encountered in linkage analysis of familial Alzheimer's disease. We used two- locus models to represent the possible existence of two disease genes while allowing for intrafamilial heterogeneity, and modeled the occurrence of the

The power of two-locus affected sib-pair
The power of two-locus affected sib-pair linkage analysis to detect interacting disease loci
✍ Ingileif B. Hallgrímsdóttir; Terence P. Speed 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views

## Abstract It has been shown that two‐locus linkage analysis can, for some two‐locus disease models, be used to detect effects at disease loci that do not reach significance in a genome scan. However, few examples exist where two‐locus linkage has been successfully used to map genes. We study the

Cloning of two loci for synapse protein
Cloning of two loci for synapse protein Snap25 in zebrafish: Comparison of paralogous linkage groups suggests loss of one locus in the mammalian lineage
✍ Carl Risinger; Erik Salaneck; Charlotte Söderberg; Michael Gates; John H. Postle 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB

Synaptosome-associated protein of 25 kDa (Snap25) is an intracellular protein that is defined as a target receptor for synapse vesicles prior to neurotransmitter release. Snap25 is highly conserved, with 61% identity between human and Drosophila melanogaster. Whereas mammals and chicken have a singl