Two new approaches toward linkage heterogeneity of FAD: Two-locus models and age of onset as a discriminator
✍ Scribed by Dr. Chantal Mérette; Thomas Lehner; Jurg Ott
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 272 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
We present two new approaches to the problem of genetic heterogeneity encountered in linkage analysis of familial Alzheimer's disease. We used two- locus models to represent the possible existence of two disease genes while allowing for intrafamilial heterogeneity, and modeled the occurrence of the early onset form of the disease with epistasis. We developed a mixture model of heterogeneity where the early and late onset family types can be either linked to chromosome 19, 21, or unlinked, and where it is not necessary to arbitrarily preclassify a family into an early or late onset family type. cb 1993 Wiley-Liss, Inc.