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Linkage detection tests under heterogeneity

✍ Scribed by Dr. Neil Risch; D. C. Rao

Book ID
102225554
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
439 KB
Volume
6
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

A two-parameter (admixture) test (Lod,) for the detection of linkage which allows for heterogeneity is described. Lod score values for this test which lead to comparable type 1 error probabilities as the conventional (homogeneous) single-parameter lod score test (Lod,) are derived. For example, a Lod2 value of 3.70 corresponds to the conventional lod score (Lod,) value of 3.0. In terms of power to detect linkage, the Lodz test is advantageous only for moderate to large pedigrees (autosomal dominant inheritance with high penetrance) and when the proportion of linked families is low (less than 40%). Otherwise, there appears to be no serious disadvantage in using the conventional Lod, test when heterogeneity is present.

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