𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Linkage analysis suggests at least two loci for X-linked nonspecific mental retardation

✍ Scribed by Arveiler, B. ;Alembik, Y. ;Hanauer, A. ;Jacobs, P. ;Tranebjaerg, L. ;Mikkelsen, M. ;Puissant, H. ;Piet, L. Larget ;Mandel, J. L.


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
472 KB
Volume
30
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Linkage analysis in three families with
✍ Claes, S.; Gu, X. X.; Legius, E.; Lorenzetti, E.; Marynen, P.; Fryns, J. P.; Cas πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 155 KB

Nonspecific X-linked mental retardation (XLMR) is a common disorder. The number of genes involved in this condition is not known, but it is estimated to be more than 10. We present a clinical and linkage study on 3 families with XLMR. All families were analyzed using highly polymorphic markers cover

Linkage analysis in a large family with
✍ Glass, I. A. ;White, E. M. ;Pope, M. J. ;Pirrit, L. A. ;Cockburn, F. ;Connor, J. πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 629 KB

We report on a large 5-generation family with "nonspecific" X-linked mental retardation. Nine living affected males have an I& between 50 and 70 but have normal stature, facial appearance, and testicular volumes and no other abnormalities. Two obligate carrier females had borderline intellectual abi

Four families (MRX43, MRX44, MRX45, MRX5
✍ Hamel, Ben C.J.; Smits, Arie P.T.; van den Helm, Bellinda; Smeets, Dominique F.C πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 185 KB πŸ‘ 1 views

Four families are described in which mental retardation segregates in an X-linked fashion. Mental retardation was the only consistent clinical finding in all affected males. The degree of retardation varied from mild to profound both between and within families. Linkage analysis localized the geneti

Mapping to distal Xq28 of nonspecific X-
✍ Russo, S. ;Cogliati, F. ;Cavalleri, F. ;Cassitto, M.G. ;Giglioli, R. ;Toniolo, D πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 281 KB πŸ‘ 2 views

Families with mentally retarded males found to be negative for FRAXA and FRAXE mutations are useful in understanding the genetic basis of X-linked mental retardation. According to the most recent data (updated to 1999), 69 MRX loci have been mapped and 6 genes cloned. Here we report on a linkage stu

Regional localization of two genes for n
✍ Claes, S.; Vogels, A.; Holvoet, M.; Devriendt, K.; Raeymaekers, P.; Cassiman, J. πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 63 KB πŸ‘ 2 views

Two families with nonspecific X-linked mental retardation (XLMR) are presented. In the first family, MRX49, 5 male patients in 2 generations showed mild to moderate mental retardation. Two-point linkage analysis with 28 polymorphic markers, dispersed over the X-chromosome, yielded a maximal LOD scor