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Linkage Analysis of BRCA1 in Japanese Breast Cancer Families

โœ Scribed by Inoue, Rie ;Fukutomi, Takashi ;Ushijima, Toshikazu ;Matsumoto, Yoshiro ;Sugimura, Takashi ;Nagao, Minako


Book ID
108580930
Publisher
Wiley (Blackwell Publishing)
Year
1994
Tongue
English
Weight
345 KB
Volume
85
Category
Article
ISSN
0910-5050

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Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon