Hereditary breast cancer and linkage analysis to BRCA1
β Scribed by Mr A. G. McKinley; S. E. H. Russell; R. A. J. Spence; W. Odling-Smee; N. C. Nevin
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 385 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0007-1323
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A G G, 1240C G
## BACKGROUND. The purpose of this investigation was to elucidate the clinicopathologic characteristics of BRCA1-and BRCA2-associated hereditary breast carcinomas (HBCs) in Japanese women.
The recent discovery of the breast cancer-associated genes BRCA1 and BRCA2 has changed the clinical care provided to women at high risk of breast cancer. We will review what is currently known about the clinical management of patients who bear (or are suspected of bearing) mutations in either of the
Women harboring BRCA1 germline mutations carry an 85% lifetime risk of developing breast cancer and a 63% risk of ovarian cancer. In this first systematic study of familial breast and/or ovarian cancer in Germany we investigated 29 families for germline mutations in the BRCA1 gene. We identified mut
We identified 17 BRCA1 mutations in 86 Austrian breast and ovarian cancer families (20%) that were screened for mutations by denaturing high-performance liquid chromatography (DHPLC) and the protein truncation test (PTT). Eleven distinct mutations were detected, 4 of them (962del4, 2795del4, 3135del