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Limitations and factors affecting the lactam reduction approach to the synthesis of anthramycin analogs

✍ Scribed by David E. Thurston; Pravin T.P. Kaumaya; Laurence H. Hurley

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
275 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

The limitations and factors affecting the hydride reduction of pyrrolo[l,4]benzodiazepine-5,10-diones to anthramycin-type analogs have been explored. Anthramycin, sibiromycin, tomaymycin and the neot;ramycins belong to the pyrrolo[l,4] benzodiazepine(P[1,4]B)group of antitumor antibiotics. Previous Jnvestigations have provided information on the precise manner in ;hich these drugs biid to DNA and on the probable features responsible for their cardiotoxicity. We have suggested4 a rational approach to the development of clinically useful drugs in this series, and have embarked upon investigations designed to provide versatile synthetic methodologies which should allow us to5test our SAR predictions.

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