๐”– Bobbio Scriptorium
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Ligands and Protecting Groups: The t-Butyl Advantage

โœ Scribed by Christopher J. Woltermann


Publisher
John Wiley and Sons
Year
2004
Weight
49 KB
Volume
35
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


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The practical preparation of N-silylated carbamates (typified by 1) is reported. These compotmds are synthesized in high yields by treating N-t-Boc.protected primary amines with silyl trillate reagents in dichlofomethane in the presence of triethylamine.

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Di-t-butyldichlorosilane reacts with diols to yield the corresponding ai-J-butylsilylene derivatives. This useful protecting group is readily removed by treatment with pyridinium hydrofluoride. In conjunction with our synthetic efforts directed toward pillaromycinone (I), we required a diol protect