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The di-t-butylsilylene protecting group for diols

โœ Scribed by Barry M. Trost; Charles G. Caldwell

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
217 KB
Volume
22
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Di-t-butyldichlorosilane reacts with diols to yield the corresponding ai-J-butylsilylene derivatives. This useful protecting group is readily removed by treatment with pyridinium hydrofluoride.

In conjunction with our synthetic efforts directed toward pillaromycinone (I), we required a diol protecting group having the following properties: 1) stability to Lewis acids, 2) ability to be removed chemoselectively

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