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Selective cleavage of the t-butyloxycarbonyl protecting group

โœ Scribed by C.J. Gray; A.M. Khoujah

Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
209 KB
Volume
10
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A disadvantage in the use of the t-butyloxycarbonyl(BOC) groupls2 for N-protection in peptide synthesis is that the acidic conditions normally employed for its removal 3*495 also effect the cleavage of the t-butyl ester group. The latter is used mainly to

๐Ÿ“œ SIMILAR VOLUMES

Thermolytic removal of t-butyloxycarbony
Thermolytic removal of t-butyloxycarbonyl (BOC) protecting group on indoles and pyrroles
โœ Viresh H. Rawal; Michael P. Cava ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 138 KB

The t-Butyloxycarbonyl (BOC) group on indoles and pyrroles can be removed cleanly and in high yield by simple thermolysis: no acid, no base, no solvent is required. In recent years considerable attention has been given to the problem of finding suitable protecting groups for indoles and pyrroles.2