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Selective removal of the t-butyloxycarbonyl protecting group in the presence of t-butyl and p-methoxybenzyl esters

โœ Scribed by Jennifer Goodacre; Hoger John Ponsford; Irene Stirling

Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
179 KB
Volume
16
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

t-Butyloxycarbonyl (BOC) amino acids are frequently used ae intermediates in peptide synthesis and the reagents normally used for the removal of the protecting group 1,2,3 _

๐Ÿ“œ SIMILAR VOLUMES

Selective cleavage of the t-butyloxycarb
Selective cleavage of the t-butyloxycarbonyl protecting group
โœ C.J. Gray; A.M. Khoujah ๐Ÿ“‚ Article ๐Ÿ“… 1969 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 209 KB

A disadvantage in the use of the t-butyloxycarbonyl(BOC) groupls2 for N-protection in peptide synthesis is that the acidic conditions normally employed for its removal 3\*495 also effect the cleavage of the t-butyl ester group. The latter is used mainly to

Thermolytic removal of t-butyloxycarbony
Thermolytic removal of t-butyloxycarbonyl (BOC) protecting group on indoles and pyrroles
โœ Viresh H. Rawal; Michael P. Cava ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 138 KB

The t-Butyloxycarbonyl (BOC) group on indoles and pyrroles can be removed cleanly and in high yield by simple thermolysis: no acid, no base, no solvent is required. In recent years considerable attention has been given to the problem of finding suitable protecting groups for indoles and pyrroles.2