✦ LIBER ✦

Laser spray: electric field-assisted matrix-assisted laser desorption/ionization

✍ Scribed by Kenzo Hiraoka

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 226 KB
Volume: 39
Category: Article
ISSN: 1076-5174
DOI: 10.1002/jms.621

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✦ Synopsis

Abstract

A new liquid chromatography/mass spectrometry interface, the laser spray, has been developed. Explosive vaporization and mist formation occur when an aqueous solution effusing out from the tip of the stainless‐steel capillary is irradiated from the opposite side of the capillary by a 10.6 µm infrared laser. Weak ion signals could be detected when the plume was sampled through the ion sampling orifice. When a high voltage (3–4 kV) was applied to the stainless‐steel capillary, strong ion signals appeared. The ion abundances were found to be orders of magnitude greater than those obtained by conventional electrospray ionization in the case of aqueous solutions. The present method is regarded as an electric‐field assisted form of matrix‐assisted laser desorption/ionization in which the liquid chromatographic solvent (water, etc.) acts as a liquid matrix. Laser spray ionization is expected to become a versatile method for biological mass spectrometry because this method is compatible with the natural solvent, water. Copyright © 2004 John Wiley & Sons, Ltd.

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