Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms
β Scribed by C. Coutelle; P. J. Ward; B. Fleury; P. Quattrocchi; H. Chambrin; A. Iron; P. Couzigou; A. Cassaigne
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 49 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Glutathione S-transferases (GSTs) belong to a superfamily of detoxification enzymes that provide critical defences against a large variety of chemical carcinogens and environmental toxicants. GSTs are present in most epithelial tissues of the human gastrointestinal tract. We investigated association
Background. The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens (GSTT1, GSTM1, GSTP1) and one polymorphism of a DNA repair gene (XRCC1) for patients diagnosed with squamous cell carcinoma (SCC). Methods.
## Abstract Tobacco smoke and ionizing radiation induce oxidative stress by transmitting or generating reactive oxygen species (ROS). We hypothesized that glutathioneβ__S__βtransferase M1 (__GSTM1__) null homozygotes would have decreased ability to neutralize ROS that might increase their susceptib
## Abstract ## Background. Factors determining the individual susceptibility to head and neck squamous cell carcinoma (HNSCC) are still largely unknown. An imbalance between enzymes involved in the toxification and detoxification of (pre)βcarcinogens closely related to HNSCC, which may appear duri