Genetic polymorphisms of glutathione S-transferase M1 and bladder cancer risk: a meta-analysis of 26 studies
β Scribed by RongGui Zhang; GuangYong Xu; WenJun Chen; WeiLi Zhang
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 256 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0301-4851
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Background. We sought to evaluate the estimated risk of GSTM1 null genotype and squamous cell carcinoma of the head and neck (SCCHN). Methods. The studies done so far for GSTM1 null genotype as a risk factor associated with head and neck cancer are not conclusive and have shown conflicting results.
Glutathione S-transferases (GSTs) belong to a superfamily of detoxification enzymes that provide critical defences against a large variety of chemical carcinogens and environmental toxicants. GSTs are present in most epithelial tissues of the human gastrointestinal tract. We investigated association