We studied 58 splicing mutations originating in observed. The predicted change in three of the base vivo at the hypoxanthine guanine phosphoribosyl-substitutions would be a stop codon. The tandem transferase (HPRT) locus in T-cells of 30 nonsmoking mutation (CC r TT) occurred at position 550-551, ma
β¦ LIBER β¦
Large deletions are tolerated at the hprt locus of in vivo derived human T-lymphocytes
β Scribed by James C. Fuscoe; Lisa J. Zimmerman; Karen Harrington-Brock; Martha M. Moore
- Book ID
- 113255647
- Publisher
- Elsevier Science
- Year
- 1992
- Weight
- 617 KB
- Volume
- 283
- Category
- Article
- ISSN
- 0165-7992
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Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m