In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes
β Scribed by Janice A. Nicklas; J.Patrick O'Neill; Timothy C. Hunter; Michael T. Falta; Malcolm J. Lippert; David Jacobson-Kram; Jerry R. Williams; Richard J. Albertini
- Book ID
- 113194041
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 876 KB
- Volume
- 250
- Category
- Article
- ISSN
- 0027-5107
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π SIMILAR VOLUMES
Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m
We studied 58 splicing mutations originating in observed. The predicted change in three of the base vivo at the hypoxanthine guanine phosphoribosyl-substitutions would be a stop codon. The tandem transferase (HPRT) locus in T-cells of 30 nonsmoking mutation (CC r TT) occurred at position 550-551, ma