The lactate dehydrogenases of HeLa cells grown in an anaerobic environment with either glucose or L-lactate have a higher ratio of A to B subunits than do the same cells grown in an aerobic environment. This ratio is decreased when the anaerobic environment is made aerobic during cell growth, or whe
✦ LIBER ✦
Lactate Dehydrogenase Isozymes during Dedifferentiation in Cultures of Mammary Secretory Cells
✍ Scribed by BLANCO, ANTONIO; RIFÉ, UBALDO; LARSON, B. L.
- Book ID
- 109656340
- Publisher
- Nature Publishing Group
- Year
- 1967
- Tongue
- English
- Weight
- 432 KB
- Volume
- 214
- Category
- Article
- ISSN
- 0028-0836
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Early studies, using kinetic methods, suggested that the isozyme pattern of lactate dehydrogenase in various cells oscillated with time. More recent electrophoretic studies on murine erythroleukaemic cells (which exhibit only one isozyme) indicated very high frequency variations (period 2min or less