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Lactam Synthesis via the Intramolecular Hydroamidation of Alkynes Catalyzed by Palladium Complexes

✍ Scribed by Patil, Nitin T.; Huo, Zhibao; Bajracharya, Gan B.; Yamamoto, Yoshinori

Book ID
127297893
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
85 KB
Volume
71
Category
Article
ISSN
0022-3263

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## Abstract A robust one‐pot process has been developed for the synthesis of a variety of polycyclic indole skeletons __via__ a consecutive sequence of hydroamidation and palladium‐catalyzed annulation, from inexpensive 2‐chloroanilines bearing tethered acetylenes.