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Lactam Synthesis via the Intramolecular Hydroamidation of Alkynes Catalyzed by Palladium Complexes.

✍ Scribed by Nitin T. Patil; Zhibao Huo; Gan B. Bajracharya; Yoshinori Yamamoto


Publisher
John Wiley and Sons
Year
2006
Weight
15 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract A robust one‐pot process has been developed for the synthesis of a variety of polycyclic indole skeletons __via__ a consecutive sequence of hydroamidation and palladium‐catalyzed annulation, from inexpensive 2‐chloroanilines bearing tethered acetylenes.