Indole Synthesis via Palladium-Catalyzed Intramolecular Cyclization of Alkynes and Imines
β Scribed by Takeda, Akira; Kamijo, Shin; Yamamoto, Yoshinori
- Book ID
- 121206677
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 105 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Catalytic amounts of Pd(OAc)2 in the presence of c-Bu4NC1, OMF and an appropriate Et3N) cyclize nitrogen-containing o-lodoaryl alkenes to indoles, quinolines, isoquinolines and isoquTnolones in short reaction times, under mild temperatures, and in high yields. Transition metal reagents have proven h
A novel synthetic strategy based on the intramolecular palladium-catalyzed oxidative cyclization reaction, allows the formation of C-C bond and the synthesis of b-carbolinones. The reaction has been performed in the presence of catalytic amount of PdCl 2 (CH 3 CN) 2 and benzoquinone as a reoxidant.