## Abstract The BALB/c mouse model of Niemann‐Pick type C (NPC) disease exhibits neuropathological similarities to the human condition. There is an age‐related cerebral atrophy, demyelination of the corpus callosum, and degeneration of cerebellar Purkinje cells in the NPC mouse. In human NPC, many
Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann–Pick C1
✍ Scribed by Ivan A. Borbon; Zach Hillman; Ernesto Duran Jr.; Pawel R. Kiela; Sally A. Frautschy; Robert P. Erickson
- Book ID
- 113842362
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 537 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0091-3057
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📜 SIMILAR VOLUMES
## Abstract Niemann‐Pick disease type C (NPC) is a deadly neurodegenerative disease often caused by mutation in a gene called NPC1, which results in the accumulation of unesterified cholesterol and glycosphingolipids in the endosomal–lysosomal system. Most studies on the mechanisms of neurodegenera
## Abstract Niemann‐Pick type C1 (NPC1) disease is an autosomal‐recessive cholesterol‐storage disorder characterized by liver dysfunction, hepatosplenomegaly, and progressive neurodegeneration. The NPC1 gene is expressed in every tissue of the body, with liver expressing the highest amounts of NPC1