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Labelling of a new serotoninergic ligand : [18F]ritanserin

✍ Scribed by C. Crouzel; N. Venet; G. Sanz; A. Denis

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
188 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

SUI(IvLRY

Ritanserin

has been labelled with 18F to visualize the serotoninergic receptors by Positron Emission Tomography (PET). The synthesis was carried out by a nucleophilic substitution of a nitro substituent of a ni trophenylketone by 18F-and then addition of a Grignard reagent to the ketone folloved by dehydration of the tertiary alcohol so formed. The total time to have ["Plritanserin ready for injection into a was 150 minutes (after the end of bombardement for the 18P production patient P o (p,n) %). The labelling technique described was used to obtain 1.1 to 1.5 GBq 18 (30 to 40 mCi) of [ PIRitanserin with a specific activity of 44 GBq/lrmol (1.2 Ci/pmol) starting from 18.5 GBq (500 m C i ) 18F.

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