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Labelling and metabolism of methionine-methyl-11C

✍ Scribed by Dominique Comar; Jean-Claude Cartron; Mariannick Maziere; Christian Marazano

Book ID
104683822
Publisher
Springer
Year
1976
Tongue
English
Weight
399 KB
Volume
1
Category
Article
ISSN
0340-6997

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✦ Synopsis

Carbon 11 which is a 20.4 minutes half life isotope emitting positrons was used for methionine labelling on the methyl group by action of 11C-methyl-iodide on DL or L homocysteine. With the method described, 20 to 30 mCi of 11C-methyl-methionine (Specific activity 50 mCi/muM) may be obtained within 25 minutes. The 20 Mev proton beam used for 11C production was 10 muA. The metabolism of 11C methionine studied on mice shows a high uptake in pancreas and to a smaller extent in brain. On humans sequential images were obtained at the head level which allowed measurement of the uptake of the radio-labelled compound in the brain so as to study the radioactivity curve in different parts of the organ.

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