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Improved preparation of l-[Methyl-11C]methionine by on-line [11C]methylation

✍ Scribed by Ken-Ichiro Mizuno; Shigeki Yamazaki; Ren Iwata; Claudio Pascali; Tatsuo Ido

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 292 KB
Volume: 44
Category: Article
ISSN: 0969-8043
DOI: 10.1016/0969-8043(93)90152-z

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✦ Synopsis

On-line ["Clmethylation using ["Clmethyl iodide has been successfully applied to the preparation of L-[methyl-"Clmethionine ("C-Met). ["C]Methyl iodide is first trapped in a short column that contains Porapak Q and L-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture ofethanol and water to cause the ["Clmethylation.

The present method can provide practically pure "C-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.

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