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Labelled compounds of potential biological interest. IV. Tritium labelling of some cyclzing compounds

✍ Scribed by Tamas Gosztonyi; Karl Erik Domeij; Svante Ross

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
450 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Quaternary ammonium compounds formed at the site of action by spontaneous cyclization of tertiary ω‐haloalkylamine precursors may have interesting pharmacological properties. In order to study the pharmacokinetics of the cyclization principle, a series of new tertiary ω‐haloalkylamines derived from p‐chloroamphetamine has been synthesized both unlabelled and labelled with tritium at high specific activity.

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