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Labelled compounds of potential biological interest. V. Preparation of some hypolipidemic agents labelled with tritium

✍ Scribed by Tamas Gosztonyi; Göran Bondesson; Karl Erik Domeij; Nils E. Stjernstroum

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
328 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Two hypolipidemic aryloxyacetic acid derivatives and one aryloxy‐methylmalonic acid derivative were labelled with tritium in the aryloxy moiety. The corresponding phenols were first labelled by the Yavorsky method and then transformed to the desired products by synthetic reaction steps. For comparative pharmacokinetic and metabolic studies the carboxylic acid corresponding to clofibrate was also labelled by the same procedure.

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