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L-ASPARAGINASE, ANTITHROMBIN III, AND THROMBOSIS

✍ Scribed by Conard, J.; Cazenave, B.; Maury, J.; Horellou, M.H.; Samama, M.

Book ID
122929751
Publisher
The Lancet
Year
1980
Tongue
English
Weight
123 KB
Volume
315
Category
Article
ISSN
0140-6736

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## Abstract The effect of L‐asparaginase (L‐asp) therapy on circulating antithrombin‐III (AT‐III) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for AT‐III by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum AT‐III leve

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## Abstract Antithrombin III levels were measured in serum before, during, and after therapy with three different dosage regimens of L‐asparaginase in 11 children with acute lymphoblastic leukemia. Levels determined by both functional and immunologic methods were transiently reduced during alternat