𝔖 Bobbio Scriptorium
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L-asparaginase effect on antithrombin-III levels

✍ Scribed by Anderson, Norwood ;Lokich, Jacob J. ;Tullis, James L.

Book ID
102520499
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
345 KB
Volume
7
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

The effect of L‐asparaginase (L‐asp) therapy on circulating antithrombin‐III (AT‐III) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for AT‐III by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum AT‐III levels, followed by a protracted recovery beyond the period of L‐asp exposure. One of the three patients developed a reversible venous thrombosis of the arm. The mechanism of the L‐asparaginase effect may be related to peripheral degradation of AT‐III or to inhibition of production.

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Previous reports have observed a fall in antithrombin III (AT III) concentration in patients receiving L-asparaginase as part of acute lymphatic leukaemia (ALL) induction therapy. The aim of this study was to define any qualitative changes in AT III that might arise during the course of L-asparagina