𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reduced antithrombin III levels during L-asparaginase therapy

✍ Scribed by Buchanan, George R. ;Holtkamp, Christine A.

Book ID
102949745
Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
517 KB
Volume
8
Category
Article
ISSN
0098-1532

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Antithrombin III levels were measured in serum before, during, and after therapy with three different dosage regimens of L‐asparaginase in 11 children with acute lymphoblastic leukemia. Levels determined by both functional and immunologic methods were transiently reduced during alternate‐day or daily L‐asparaginase treatment but not affected when the drug was administered only every 10 days. The probable mechanism of this effect is impaired hepatic synthesis of antithrombin III, resembling the acute and transient deficiency of other asparagine‐rich proteins during L‐asparaginase administration.

📜 SIMILAR VOLUMES

L-asparaginase effect on antithrombin-II
L-asparaginase effect on antithrombin-III levels
✍ Anderson, Norwood ;Lokich, Jacob J. ;Tullis, James L. 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 345 KB

## Abstract The effect of L‐asparaginase (L‐asp) therapy on circulating antithrombin‐III (AT‐III) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for AT‐III by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum AT‐III leve

Depression of functional and antigenic p
Depression of functional and antigenic plasma antithrombin III (AT-III) due to therapy with L-asparaginase
✍ Howard A. Liebman; Jerry K. Wada; Mary Jane Patch; William McGehee 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 451 KB

Eleven patients with leukemia and lymphoma were treated with 14 courses of E. coli L-asparaginase. Abnormalities of the coagulation screening tests and decreased fibrinogen levels were observed in all patients during treatment. Significant depressions of functional (mean 32%) and antigenic (mean 48%

Increased antithrombin III concentration
Increased antithrombin III concentration in children with acute lymphatic leukaemia receiving L-asparaginase therapy
✍ O'Meara, Anne ;Daly, Martina ;Hallinan, F. H. 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB

Previous reports have observed a fall in antithrombin III (AT III) concentration in patients receiving L-asparaginase as part of acute lymphatic leukaemia (ALL) induction therapy. The aim of this study was to define any qualitative changes in AT III that might arise during the course of L-asparagina