## Abstract The effect of Lβasparaginase (Lβasp) therapy on circulating antithrombinβIII (ATβIII) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for ATβIII by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum ATβIII leve
Antithrombin III Concentrations Associated With L-Asparaginase Administration
β Scribed by Carol P. Mandell; Sharron L. O'Neill; Bernard F. Feldman
- Book ID
- 114950948
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 278 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0147-0701
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π SIMILAR VOLUMES
Previous reports have observed a fall in antithrombin III (AT III) concentration in patients receiving L-asparaginase as part of acute lymphatic leukaemia (ALL) induction therapy. The aim of this study was to define any qualitative changes in AT III that might arise during the course of L-asparagina
## Abstract Antithrombin III levels were measured in serum before, during, and after therapy with three different dosage regimens of Lβasparaginase in 11 children with acute lymphoblastic leukemia. Levels determined by both functional and immunologic methods were transiently reduced during alternat
Eleven patients with leukemia and lymphoma were treated with 14 courses of E. coli L-asparaginase. Abnormalities of the coagulation screening tests and decreased fibrinogen levels were observed in all patients during treatment. Significant depressions of functional (mean 32%) and antigenic (mean 48%