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Kinetic and mechanistic investigation of the selective acidolysis of the C-terminal amide bond of N-acyl-N,α,α-trialkyl glycine amides

✍ Scribed by Wei-Qun Jiang; Cristina Ventura; Susana P.G. Costa; Lídia Albuquerque; Raquel Gonçalves-Maia; Hernâni L.S. Maia


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
183 KB
Volume
11
Category
Article
ISSN
1075-2617

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The C-terminal amide bond of N-acyl-N,alpha,alpha-trialkyl glycine amides is labile to acid and this has been currently assigned to steric crowding within the amino acid residue. However, our previous work has shown that in the acidolysis of some of these compounds steric hindrance seems to play a l