Kinetic investigation of the effect of the amino acid side chains in the selective acidolysis of N-acyl-N,α,α-trialkyl glycine amides
✍ Scribed by Wei-Qun Jiang; Sílvia M. M. A. Pereira-Lima; Cristina Ventura; Susana P. G. Costa; Lídia Albuquerque; Raquel Gonçalves-Maia; Hernâni L. S. Maia
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 137 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.673
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📜 SIMILAR VOLUMES
The C-terminal amide bond of N-acyl-N,alpha,alpha-trialkyl glycine amides is labile to acid and this has been currently assigned to steric crowding within the amino acid residue. However, our previous work has shown that in the acidolysis of some of these compounds steric hindrance seems to play a l
Four new N-Fmoc cc-amino acids carrying a nucleobase in the side chain were prepared starting from L-glutamic acid. N-Boc-glutamic acid ct benzyl ester underwent a radical decarboxylation in the presence of CBrCl3 to give the corresponding 2-amino-4-bromobutanoic acid derivative. The four nucleobase