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Kalihinene and isokalihinol B, cytotoxic diterpene isonitriles from the marine sponge Acanthella klethra

✍ Scribed by N. Fusetani; K. Yasumuro; H. Kawai; T. Natori; L. Brinen; J. Clardy

Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 274 KB
Volume: 31
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)94453-8

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✦ Synopsis

Kalihinene and isokalihinol B. cytotoxic diterpene isonitriles have been isolated from the marine sponge Acanthclla klethra. Structures of these compounds were elucidated by interpretation of NMR spectra as well as by single crystal X-ray diffraction. Marine sponges of the order Halichondrida often contain sesquiterpene isonitriles and diterpene isonitriles which show a broad spectrum of biological activities, including antimicrobial and ichthyotoxic properties. 2 In our screening for antifungal and cytotoxic metabolites in Japanese marine invertebrates, the marine sponge Acanthella klethra

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