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Jaspines A and B: two new cytotoxic sphingosine derivatives from the marine sponge Jaspis sp.

✍ Scribed by Véronique Ledroit; Cécile Debitus; Catherine Lavaud; Georges Massiot

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 125 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02541-8

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✦ Synopsis

The ethanolic extract of the sponge Jaspis sp. collected in Vanuatu showed cytotoxicity against KB tumour cells (IC 95 =10 mg/ml). A bioassay-guided fractionation led to the isolation of two new cytotoxic sphingosine derivatives, jaspine A and jaspine B. Structures were elucidated by spectroscopic methods, and absolute configuration by chemical derivatisation. The cytotoxicity of jaspine B hydrochloride was evaluated against the A549 lung tumour cell line (IC 50 =3.4×10 -7 M).

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