K Region Fission and Addition Products of 7,12-Dimethylbenz[a]anthracene 1
β Scribed by HADLER, HERBERT I.; KRYGER, ALLEN C.
- Book ID
- 127130168
- Publisher
- American Chemical Society
- Year
- 1960
- Tongue
- English
- Weight
- 798 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0022-3263
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## Abstract Female SpragueβDawley rats were given a subcutaneous injection of the parent hydrocarbon or its Kβregion epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. The parent compounds, benzo(a)__pyrene (0.2 ΞΌmol
Methanolysis of the K-region epoxide of 7,12-dimethylbenz (a) anthracene (DMBA) gave rise to two hydroxy-methoxy derivatives which were dehydrated to S-methoxy-DMBA and 6-methoxy-DMBA at a ratio of 5: 1. The data indicate that methanol attacks preferentially at the 5-position of the arene oxide. The
## Abstract One of the most potent carcinogens is 7,12βdimethylbenz(a)anthracene (7,12βDMBA), which is used routinely to conduct studies to evaluate carcinogen inhibitors. Its pharmacokinetics have not been reported in the literature. In view of its significant effects on drug metabolizing enzymes