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JAK2 and MPL Mutations in Myeloproliferative Neoplasms

โœ Scribed by Koppikar, Priya; Levine, Ross L.


Book ID
120170419
Publisher
S. Karger AG
Year
2008
Tongue
English
Weight
244 KB
Volume
119
Category
Article
ISSN
0001-5792

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Novel mutations and their functional and
โœ Tefferi, A ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 548 KB

Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis. Beginning in early 2005, a number of novel mutations involving Janus kinase 2 (__JAK2)__, Myeloproliferative Leuke