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JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science

โœ Scribed by Kilpivaara, O; Levine, R L


Book ID
109886589
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
114 KB
Volume
22
Category
Article
ISSN
0887-6924

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Novel mutations and their functional and
โœ Tefferi, A ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 548 KB

Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis. Beginning in early 2005, a number of novel mutations involving Janus kinase 2 (__JAK2)__, Myeloproliferative Leuke