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LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations

โœ Scribed by Pardanani, A; Lasho, T; Finke, C; Oh, S T; Gotlib, J; Tefferi, A


Book ID
109887205
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
350 KB
Volume
24
Category
Article
ISSN
0887-6924

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Novel mutations and their functional and
โœ Tefferi, A ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 548 KB

Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis. Beginning in early 2005, a number of novel mutations involving Janus kinase 2 (__JAK2)__, Myeloproliferative Leuke