Isotope Exchange of Azidothymidine with Tritium
β Scribed by G. V. Sidorov; Yu. B. Zverkov; N. F. Myasoedov
- Book ID
- 110419275
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 33 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1066-3622
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π SIMILAR VOLUMES
The synt esis of 3H-labelled azidothymidine (AZT) from accomplished by column chromatography. The purity of the labelled compound was determined by high performance 1 iquid chromatography connected with a radioactive flow detector. The labelled AZT was found to be stable at pH ranging from 2.3 to 7.
## Abstract The results of the synthesis of 11 different tritiated alkylxanthines by solidβphase catalytic isotope exchange are described. ^3^HβNMR analysis of the labelled compounds shows that in contrast to liquidβphase isotope exchange the tritium label is incorporated not only in the Cβ8 (H) po
## Abstract The hydrogen isotope exchange of BrefeldinβA with tritium gas (T~2~) in 1,4βdioxane was studied over a commercial palladium catalyst supported on diatomaceous earth (5% metallic weight). The effect of the gas phase was studied. Addition of air in the gas phase led to an increase of the