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Solid-phase catalytic isotope exchange of alkylxanthines with gaseous tritium

✍ Scribed by Ju. L. Kaminski; G. P. Akulov; N. A. Patokina; S. G. Rosenberg

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
164 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The results of the synthesis of 11 different tritiated alkylxanthines by solid‐phase catalytic isotope exchange are described. ^3^H‐NMR analysis of the labelled compounds shows that in contrast to liquid‐phase isotope exchange the tritium label is incorporated not only in the C‐8 (H) position, but also in the alkyl groups. The fraction of radioactivity in an alkyl group depends on the nature and position of this group.

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✍ Anton V. Filikov; John R. Jones; Nikolai F. Myasoedov; E. Sally Ward 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 438 KB 👁 1 views

## Abstract Solid state catalytic hydrogen isotope exchange has been employed to label hen egg lysozyme with tritium. Optimization of reaction conditions so that amino acids and peptide bonds remained intact led to a tritiated product with 97% of the original enzymatic activity and 94% radiochemica