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Isosteric triphosphonate analogues of dNTP: Synthesis and substrate properties toward various DNA polymerases

โœ Scribed by A. Yu. Skoblov; A. N. Semenyuk; A. M. Murabuldaev; V. V. Sosunov; L. S. Viktorova; Yu. S. Skoblov


Book ID
111456815
Publisher
SP MAIK Nauka/Interperiodica
Year
2007
Tongue
English
Weight
304 KB
Volume
33
Category
Article
ISSN
1068-1620

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New triphosphate derivatives of carbocyclic nucleoside analogues have been synthesized and shown to be potent substrates for terminal deoxynucleotidyltransferase and/or HIV reverse transcriptase; the compounds are stable to dephosphorylation with human placental alkaline phosphatase.