## The biosynthesis by and the isolation of l-menthol-14C from Mentha arvensis grown in W O z are described. Crystals (18 mg; 3.2 mCilg) were obtained after column chromatographic purijication of the steam distillate of the leaves. Purity of greater than 99.5 % was established by gas-liquid radioc
Isolation of (−)-menthol-14C and (+)-neomenthol-14C
✍ Scribed by Stephen A Haut; Margaret T. Core
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 118 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Uniformly labelled (−)‐menthol‐^14^C and (+)‐neomenthol‐^14^C were isolated and purified from the oil of peppermint plants grown in a ^14^CO~2~ chamber by preparative high performance liquid chromatography. This procedure is much simplier than previous methods and allows for large amounts of labelled oil to be processed.
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The synthesis of 14C-labeled menthol was accomplished by preparation of 14C-labeled (&) pulegone. Catalytic hydrogenation and chemical reduction converted (&) pulegone to the isomeric menthols possessing 1.10 mCi total activity. Gas chromatographic separation of this material gave the relative abund
## Abstract Reaction of adriamycinone with excess ^14^CH~3~Mgl and periodate cleavage of the resulting glycol (5) affords daunomycinone‐14‐^14^C (6). Bromination and hydrolysis of 6 gives adriamycinone‐14‐^14^C (8). Coupling of 6 and the 14‐0‐p‐anisyldiphenyl‐methyl derivative (9) with 1‐chloro‐3‐N
The synthesis of lanosterol [la] and desmosterol [Ira] Iabeled with 14C in the 25 position by a Wittig reaction between triphenyl-214C isopropylidene-phosphorane [IVb] and the corresponding aldehydes are described. The specijic activities obtained are, respectively, 0.539 mClmM and 0.752 mClmM and t
## The synthesis of [ 4-14C]nisoldipine started from dimethyl [ 14C] formamide which was allowed to react with 2-nitrophenyllithium yielding 2-nitro [ 7-14C] benzaldehyde . Knovenagel condensation with isobutyl acetoacetate yielded isobutyl 2-(2-nitr0[7-~~C]benzylidene) acetoacetate. Key reaction
## Abstract The syntheses of 1‐m‐trifluoromethylphenyl‐2‐N‐ethylaminopropane (I; Ponderax®) and 1‐m‐trifluoromethylphenyl‐2‐N‐β‐benzoyloxyethylaminopropane (II; S780) labelled with carbon‐14 at the benzylic position have been accomplished in seven stages starting from Ba^14^CO~3~. The overall radio