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Isolation and characterization of the human mismatch repair gene hMSH2 promoter region

โœ Scribed by Scherer, StefanJ.; Seib, Thomas; Seitz, Gerhard; Dooley, Steven; Welter, Cornelius

Book ID
118771719
Publisher
Springer
Year
1996
Tongue
English
Weight
244 KB
Volume
97
Category
Article
ISSN
0340-6717

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## Background: The human mismatch repair (mmr) gene hmsh2 (human muts homolog-2) is a dna repair gene that has been reported to be mutated in 40% of hereditary nonpolyposis colon cancer (hnpcc) kindreds and a small percentage of sporadic tumors. hnpcc is a cancer predisposition syndrome with an inc