Promoter hypermethylation of mismatch repair genes, hMLH1 and hMSH2 in oral squamous cell carcinoma
✍ Scribed by R Czerninski; S Krichevsky; Y Ashhab; D Gazit; V Patel; D Ben-Yehuda
- Book ID
- 111272343
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 277 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1354-523X
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## Abstract We evaluated promoter hypermethylation of a panel of tumor suppressor genes as a means to detect epigenetic alterations in oral squamous cell carcinomas (OSCC) of Indian‐origin and compare with North‐American head and neck squamous cell carcinomas (HNSCC). Quantitative‐methylation‐speci
## Abstract Aberrant promoter hypermethylation of tumor‐associated genes leading to their inactivation is a common event in many cancer types. Using a sensitive restriction‐multiplex PCR method, we studied the promoter hypermethylation profile of the __p16, p15, hMLH1, MGMT__ and __E‐cad__ genes in