Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O 6 position of guanine. These methyl adducts are removed from DNA by the O 6 -alkylguanine DNA alkyltransferase (OGAT). The mechanism by which O 6 -methylguanine (O 6 meG) induces cell death in OGAT-d
Cell type specificity in alternative splicing of the human mismatch repair gene hMSH2
β Scribed by Clarke, Luka A; Jordan, Peter; Boavida, Maria Guida
- Book ID
- 110024966
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 215 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1018-4813
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## Background: The human mismatch repair (mmr) gene hmsh2 (human muts homolog-2) is a dna repair gene that has been reported to be mutated in 40% of hereditary nonpolyposis colon cancer (hnpcc) kindreds and a small percentage of sporadic tumors. hnpcc is a cancer predisposition syndrome with an inc
## Background: Several convincing studies have shown that the hmsh2 gene plays major roles in mismatch repair by recognizing mismatched bases and preventing mutations during dna replication. loss of this function may result in the accumulation of dna replication errors or even the mutator phenotype